Management Series

Managing HIV-Infected Patients With Initial Regimen Failure

Modules

• Understanding and Preventing Virologic Failure of Initial Antiretroviral Therapy
• Consequences of Failure: Outcomes and Options After Failure of the Initial Antiretroviral Regimen

Interactive Case Challenges

• Managing the Care of an HIV-Infected Patient With an Inaccurate Previous Treatment History
• Interactive Case Challenge (coming soon)
• Interactive Case Challenge (coming soon)

Initial Regimen Failure Pocket Guide

• Pocket Guide

The Role of Integrase Inhibitors in HIV Management

Modules

• Targeting Integrase: Mechanisms of Action and Mechanisms of Resistance to Integrase Inhibitors
• Clinical Studies of Integrase Inhibitors: A Comprehensive Review
• From Bench to Bedside: The Clinical Role of Integrase Inhibitors

Interactive Case Challenges

• Management of a Moderately Treatment-Experienced Male Using Novel Antiretroviral Agents
• Management of a Virologically Suppressed Patient Experiencing Injection Site Reactions With His Current Regimen
• Management of a Patient With Extensive Antiretroviral Experience and Persistent Low-Level Viremia

CCO Slideset

• The Role of Integrase Inhibitors in HIV Management

Expert Viewpoints

Psychiatric Disorders in HIV-Infected Patients

Modules

• Diagnosis and Treatment of Psychiatric Disorders in HIV-Infected Patients
• Impact of Psychiatric Disorders on HIV Management

Interactive Case Challenges

• Initiating Therapy in a Patient With Substance Abuse Disorder
• Managing Therapy in a Patient With Increasing Anxiety
• Managing Adherence in a Patient With Multiple Medical Disorders and an Affective Disorder

CCO Slideset

• Psychiatric Disorders in HIV-Infected Patients

When to Start, What to Use: A Master Class in the Use of First-Line Antiretroviral Therapy

Modules

• Timing of Antiretroviral Initiation in Treatment-Naive Patients
• Clinical Trials of Antiretroviral Therapy in Treatment-Naive Patients
• Antiretroviral Selection in Treatment-Naive Patients

Interactive Case Challenges

• When to Initiate Therapy in a Patient Recently Diagnosed With HIV
• Management of an HIV-Infected Treatment-Naive Diabetic Female With Dyslipidemia
• Treatment Considerations in an HIV-Infected Patient With Ongoing Methamphetamine Use

Interactive Tool

• Choosing First-Line Antiretroviral Therapy

Dyslipidemia and Other Cardiovascular Risk Factors in HIV: Causes, Clinical Significance, and Management Strategies

Modules

• Cardiovascular Risk in HIV: Disease- and Treatment-Related Mechanisms in the HAART ERA
• Practical Approaches to Evaluating and Monitoring Cardiovascular Risk in HIV-Infected Patients
• HAART and the Heart: Managing Cardiovascular Risk Through Antiretroviral Individualization
• Application of Non–HIV-Specific Management Strategies for Dyslipidemia in HIV-Infected Patients

Interactive Case Challenges

• HAART Initiation in an Overweight Female With Advanced HIV Disease
• Management of a 45-Year-Old, HIV-Infected Man With Dyslipidemia While on HAART
• Management of Dyslipidemia in a 55-Year-Old Man at Very High Cardiovascular Risk

Interactive Tool

• Lipid Effects of Antiretroviral Therapy

CCO Slidesets

• Dyslipidemia and Other Cardiovascular Risk Factors in HIV

NNRTIs in Clinical Practice: An Update

Modules

• When to Use NNRTI Agents
• Managing Adverse Effects of NNRTIs

Interactive Case Challenges

• Management of Adverse Effects in a Woman Switching From Fixed-Dose NRTIs to a DHHS-Recommended Regimen
• Treatment of a Newly Diagnosed HIV-Infected 24-Year-Old Male With Suboptimal Adherence

CCO Slidesets

• NNRTIs in Clinical Practice

Choosing an Initial Protease Inhibitor for PI-Naive Patients

Modules

• When to Use the First PI-Based Regimen
• The Choice of Protease Inhibitor for the Initial PI-based Regimen

Interactive Case Challenges

• Management of an HIV-infected, Treatment-Naive, Vietnam War Veteran With a History of Poorly Controlled Paranoid Schizophrenia
• Management of a Patient With Virologic Failure on His Initial NNRTI-Based Triple-Therapy
• Choice of an Initial PI for a Patient With Hypertension and NNRTI Resistance

CCO Slidesets

• Choosing an Initial Protease Inhibitor for PI-Naive Patients

Antiretroviral Resistance and Options for Sequencing

Modules

• Mechanisms of HIV-1 Drug Resistance
• Role of Antiretroviral Resistance Testing in Clinical Practice
• Antiretroviral Hypersusceptibility: Genetic Basis and Clinical Significance
• Strategies for Sequencing Antiretroviral Regimens: The Role of Drug Resistance
• Algorithms and Online Tools for the Interpretation of Antiretroviral Resistance

Animations

• Divergent Evolutionary Pathways for HIV Drug Resistance
• Pyrophosphorolysis: A Mechanism of HIV-1 Drug Resistance

Fine-Tuning Antiretroviral Therapy in HIV-Infected Patients With Virologic Suppression: Strategies to Address Toxicity, Convenience, and Quality of Life

Modules

• Fine-Tuning Antiretroviral Therapy to Improve Regimen Convenience
• Modifying Antiretroviral Therapy to Manage or Prevent Adverse Effects
• Evolving Strategies for Fine-Tuning Antiretroviral Therapy: Where Have We Been, Where Are We Going?

Interactive Case Challenges

• Management of a Virologically Suppressed Patient Experiencing Difficulty Adhering to His Initial NNRTI-Based Regimen
• A 36-Year-Old Male Patient With Virologic Suppression Experiencing Progressive Lipoatrophy
• A 48-Year-Old HIV-Infected Man With Hyperlipidemia on HAART

Interactive Tool

• Fine-Tuning Antiretroviral Therapy

Slideset Module

• Fine-Tuning Antiretroviral Therapy in HIV-Infected Patients With Virologic Suppression: Strategies to Address Toxicity, Convenience, and Quality of Life

Neurologic Aspects of HIV/AIDS: New Insights and Management Advances

Modules

• Neurologic Manifestations of HIV Infection
• Pathogenesis of Neurologic Complications of HIV
• Neurologic and Psychiatric Adverse Effects of Antiretroviral Agents

Interactive Case Challenges

• An HIV-Infected Man Who Presents With Subacute Neurologic Symptoms
• A Man With Advanced AIDS With an Episode of Loss of Consciousness
• An HIV-Infected Man Who Presents With Leg Weakness, Stiffness, and Sensory Disturbances

Animation

• HIV, Antiretrovirals, and the Blood Brain Barrier

Insulin Resistance and Body Shape Changes in HIV-Infected Patients

Modules

• New Insights Into the Management of Insulin Resistance in HIV-Infected Patients: Focus on Etiology and Epidemiology
• Pathogenesis and Epidemiology of Body Shape Changes Associated With HAART
• Prevention and Clinical Management of Body Shape Changes Associated With HIV-1 Infection and Antiretroviral Therapy
• Perspectives on The Risks and Benefits Associated With Antiretroviral Therapy

Interactive Case Challenges

• Lipoatrophy Management in a Male HIV-Positive Patient
• Management of Body Composition Changes in an HIV-Positive Man With Undetectable Viral Load on HAART Therapy
• Insulin Resistance in an HIV-Infected Man: Management Perspectives

Tools

• Balancing the Risks vs the Benefit of HAART

Animation

• Mechanisms of Insulin Resistance in HIV-Infected Patients

Program in Portuguese

Fixed-Dose Combination NRTIs in the Treatment of HIV Infection

Modules

• Efficacy and Safety of Fixed-Dose NRTIs
• NRTI Resistance and Fixed-Dose Antiretroviral Combinations
• Strategic Use and Sequencing of Fixed-Dose NRTIs

CCO Slidesets

• Efficacy and Safety of Fixed-Dose NRTIs
• NRTI Resistance and Fixed-Dose Antiretroviral Combinations
• Strategic Use and Sequencing of Fixed-Dose NRTIs

Interactive Case Challenges

• Management of Adverse Effects in a Man Initiating Antiretroviral Therapy Using Fixed-Dose NRTIs
• Management of Emergent Drug Resistance Following HAART Initiation With Fixed-Dose NRTIs
• Management of Long-Term Toxicities in a Man Initiating Antiretroviral Therapy Using Fixed-Dose NRTIs

Pocket Guide to Antiretroviral Resistance Mutations (PDF download)

Strategies for the Management of Multiclass-Resistant Patients

Modules

• Assessing Prognosis and Treatment Goals in Multiclass-Resistant Antiretroviral-Experienced Patients
• Use and Interpretation of Resistance Tests in Multiclass-Experienced Patients
• New and Investigational Antiretroviral Agents With Activity in Multiclass-Resistant Antiretroviral-Experienced Patients
• Clinical Strategies for Maximizing the Benefits of Antiretroviral Therapy in Multiclass-Resistant Antiretroviral-Experienced Patients

Interactive Case Challenges

• Management of a Patient With Multidrug-Resistant HIV Acquired by Transmission
• Management of a Multiclass-Experienced Patient With Low-Level Viremia and Several Cardiovascular Risk Factors
• Management of a Patient With Multiple Regimen Failures and Difficult Follow-up

Slides

• Strategies for the Management of Multiclass-Resistant Antiretroviral-Experienced Patients

Interactive Tool

• Selecting a Boosted PI for the Treatment-Experienced Patient

Treatment Strategies With NNRTIs: Use in First-Line vs Later Regimens

Modules

• Characteristics of Optimal First-Line Regimens
• Antiretroviral Therapy with NNRTIs: What's the Evidence?
• Strategic Considerations in the Use of NNRTIs

Interactive Case Challenges

• Management of a Patient Initiating a First-Line NNRTI-Based HAART Regimen
• Management of a Patient With Early Virologic Failure of an Initial PI-Based HAART Regimen

The Importance of Pharmacokinetic Factors in Successful Antiretroviral Therapy

Modules

• The Importance of Pharmacokinetic and Pharmacodynamic Factors in Successful Antiretroviral Therapy—2005 in Review
• Pharmacokinetic And Pharmacodynamic Principles: A Guide For HIV Healthcare Professionals
• Factors Associated With Pharmacokinetic Variability In HIV-Infected Patients
• Integrating Pharmacokinetics Into Treatment Decisions: Strategies For Optimal Patient Care

Interactive Case Challenges

• Treatment of Tuberculosis in a Patient Coinfected With HIV
• Management of an HIV-Infected Patient With Treatment-Associated Renal Abnormalities
• Management of Antiretroviral Adverse Effects in a Young HIV-Infected Woman

CCO Expert Recaps

• The Importance of Pharmacokinetic Factors in Successful Antiretroviral Therapy

Optimizing the NRTI Backbone in HIV-Infected Patients Receiving Antiretroviral Therapy

Modules

• Safety and Tolerability of Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
• Aiming for Simplicity and Convenience in NRTI Therapy
• Switching NRTIs to Improve Safety, Tolerability, or Convenience

Interactive Case Challenges

• Avoidance and Management of NRTI Toxicities
• Optimizing Antiretroviral Therapy in a Young, Newly Diagnosed, HIV-Infected Woman
• Regarding Antiretroviral Therapy for an HIV-Infected Woman Who Plans to Become Pregnant

CCO Slidesets

• Aiming for Simplicity and Convenience in NRTI Therapy
• Safety and Tolerability of Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
• Switching NRTIs to Improve Safety, Tolerability, or Convenience

Tools

• Selecting an NRTI Backbone: An Interactive Tool

Animations

• NRTI-Induced Mitochondrial Toxicity

Double-Boosted Protease Inhibitors

Modules

• Double-Boosted Protease Inhibitor Regimens: a Pharmacologic and Pharmacokinetic Perspective
• Clinical Data on Double-Boosted Protease Inhibitor Regimens
• Potential Therapeutic Strategies Using Double-Boosted Protease Inhibitor Regimens

Interactive Case Challenges

• A Treatment-Naive Patient Infected With Multiclass-Resistant HIV
• A Patient with a History of NRTI-Associated Lactic Acidosis
• Salvage Therapy in a Multidrug-Experienced Patient

Cardiovascular Risk Factors and Metabolic Complications in Patients Receiving HAART

Modules

• Pathogenesis of Metabolic Abnormalities in HIV-Infected Patients
• Epidemiology and Evaluation of Cardiovascular Risk Factors in HIV-Infected Patients
• Individualizing HIV Care in Light of Cardiovascular Risk

Interactive Case Challenges

• Management of Hyperlipidemia in a Patient Receiving a Triple-Class Regimen
• Management of Dyslipidemia in a Highly Experienced PI-Treated Patient
• Management of an African Man with Advanced HIV Infection and Significant Cardiovascular Risk

Interactive Tools and Resources

• Impact of Different Interventions on Cardiovascular Risk in HIV-Infected Patients
• Algorithm for Management of Patients with Hyperlipidemia During PI-based Therapy

Animations

• Impact of HIV Infection and Antiretroviral Therapy on Lipid Levels: Data from MACS